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Prevalence of Parkinson's Disease

After Alzheimer's disease, the second most common neurodegenerative disorder is Parkinson’s disease. In the U.S., at least 500,000 are believed to have Parkinson’s, and about 50,000 new cases are diagnosed every year1 (I have seen other estimates of 1 million and 1.5 million — and researchers saying the numbers are consistently over-estimated while others that they are consistently under-estimated!). In the U.K., the numbers are 120,000 and 10,0002.

Most people find numbers — phone numbers, personal identification numbers, dates, and so on — more difficult to remember than words. That is, of course, why businesses try to get phone numbers that correspond to some relevant word. The system whereby this is possible — the linking of certain letters to the different digits on a telephone calling pad —is a kind of coding mnemonic. Basically, coding mnemonics are systems that transform numbers into words.

LBD: What is it?

Lewy Body Dementia is so called because the brains of affected people develop abnormal spherical masses of protein, called Lewy bodies, inside nerve cells. Lewy bodies are associated with Parkinson’s disease as well as dementia. Thus Lewy body dementia can refer to both Parkinson’s disease dementia and “dementia with Lewy bodies”. Lewy bodies are also often found in the brains of those with Alzheimer’s disease.

Unlike Alzheimer’s, however, dementia with Lewy bodies characteristically (but not invariably) begins with visual hallucinations.

The Proto-Indo-European language (PIE) is the ultimate ancestor of many European and Indian languages. The word "proto" indicates it was spoken thousands of years in the past and we have no direct record of it. What we do have is the clear evidence in its descendant languages, from the consistent patterns in the way their words vary, that there was such an ancestor. Following these patterns, scholars have deduced a quite extensive vocabulary — but they are still reconstructed, not ‘real’ words. We can never know exactly how these words were pronounced, or precisely how they were used.

On a number of occasions I have reported on studies showing that people with expertise in a specific area show larger gray matter volume in relevant areas of the brain. Thus London taxi drivers (who are required to master “The Knowledge” — all the ways and byways of London) have been found to have an increased volume of gray matter in the anterior hippocampus (involved in spatial navigation). Musicians have greater gray matter volume in Broca’s area.

To celebrate Māori Language Week here in Aotearoa (New Zealand), here's some mnemonics to help you learn 25 common words in te reo. These use the keyword mnemonic. Keywords are written in italics.

aroha (love), an arrow in the heart

awa (river), a water flowing

hīkoi (walk), hike

hui (gathering, meeting), a lot of hooey is spoken at meetings!

iti (small), itty bitty

Brain tissue is divided into two types: gray matter and white matter. These names derive very simply from their appearance to the naked eye. Gray matter is made up of the cell bodies of nerve cells. White matter is made up of the long filaments that extend from the cell bodies - the "telephone wires" of the neuronal network, transmitting the electrical signals that carry the messages between neurons.

The volume of gray matter tissue - a measure you will see cited in various reports - is a measure of the density of brain cells in a particular region.

Alzheimer's disease currently affects one in 10 people over age 65 and nearly half of those over age 85.

More than 19 million Americans say they have a family member with the disease, and 37 million say they know somebody affected with Alzheimer's.

In the United States, the average lifetime cost per Alzheimer patient is US$174,000. (These figures are from the U.S. Alzheimer's Association).

In a 1987 experiment (1), readers were presented with a text that included one or other of these sentences:

or

Both texts went on to say:

I was recently asked for advice in the case of increased “brain blocks” — failures to retrieve information that should be readily accessible. This question is, I suspect, of interest to many of my readers, so I thought I would answer it here.

There are many possible causes for an increase in this type of memory failure. These causes fall into three main categories: physical, environmental, and strategic. Let’s deal with the physical first.