After Alzheimer's disease, the second most common neurodegenerative disorder is Parkinson’s disease. In the U.S., at least 500,000 are believed to have Parkinson’s, and about 50,000 new cases are diagnosed every year1 (I have seen other estimates of 1 million and 1.5 million — and researchers saying the numbers are consistently over-estimated while others that they are consistently under-estimated!). In the U.K., the numbers are 120,000 and 10,0002.
Michael Gove is reported as saying that ‘Learning facts by rote should be a central part of the school experience’, a philosophy which apparently underpins his shakeup of school exams. Arguing that "memorisation is a necessary precondition of understanding", he believes that exams that require students to memorize quantities of material ‘promote motivation, solidify knowledge, and guarantee standards’.
Humans have a long tradition of holding genes responsible for individual differences in behavior (of course, we called it "blood", then, or "family"). In the 20th century, a counter-belief arose: that it was all down to environment, to upbringing. In more recent decades, we have become increasingly aware of how tightly and complexly genes and environment are entwined.
Frontotemporal dementia is a disorder of the frontal lobes and includes what was known as primary progressive aphasia. Although it occurs far less often than Alzheimer's disease, among dementia sufferers younger than 65 it is estimated to occur at about the same rate. In other words, frontotemporal dementia is, unlike the most common dementias, not a disorder of age. Most sufferers become symptomatic in their 50s and 60s.
In the following case study, I explore in depth the issue of learning the geological time scale — names, dates, and defining events. The emphasis is on developing mnemonics, of course, but an important part of the discussion concerns when and when not to use mnemonics, and how to decide.
Phanerozoic Eon 542 mya—present
Cenozoic Era 65 mya—present
We forget someone’s name, and our response might be: “Oh I’ve always been terrible at remembering names!” Or: “I’m getting old; I really can’t remember things anymore.” Or: nothing — we shrug it off without thought. What our response might be depends on our age and our personality, but that response has nothing to do with the reason we forgot.
A 5-year study1 involving 488 people age 75 to 85 found that, for the 101 people who developed dementia, the greater the number of stimulating activities (reading, writing, doing crossword puzzles, playing board or card games, having group discussions, and playing music) they engaged in, the longer rapid memory loss was delayed. Similarly, a study2 involving 1321 randomly selected people aged 70 to 89, of whom 197 had mild cognitive impairment, has found that reading books, playing games, participating in compute
The Proto-Indo-European language (PIE) is the ultimate ancestor of many European and Indian languages. The word "proto" indicates it was spoken thousands of years in the past and we have no direct record of it. What we do have is the clear evidence in its descendant languages, from the consistent patterns in the way their words vary, that there was such an ancestor. Following these patterns, scholars have deduced a quite extensive vocabulary — but they are still reconstructed, not ‘real’ words. We can never know exactly how these words were pronounced, or precisely how they were used.
Several genes have been implicated in Alzheimer's, but the big one is the e4 allele of the ApoE gene (on chromosome 19). This variant is found in about a quarter of the population.
Having it doesn't mean you are foreordained to develop Alzheimer's, but it certainly increases the risk substantially. The risk goes up considerably more if both of your genes are the e4 variant (remember you inherit two: one from each parent).