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Genes

Several genes have been implicated in Alzheimer's, but the big one is the e4 allele of the ApoE gene (on chromosome 19). This variant is found in about a quarter of the population.

Having it doesn't mean you are foreordained to develop Alzheimer's, but it certainly increases the risk substantially. The risk goes up considerably more if both of your genes are the e4 variant (remember you inherit two: one from each parent).

Prevalence of Parkinson's Disease

After Alzheimer's disease, the second most common neurodegenerative disorder is Parkinson’s disease. In the U.S., at least 500,000 are believed to have Parkinson’s, and about 50,000 new cases are diagnosed every year1 (I have seen other estimates of 1 million and 1.5 million — and researchers saying the numbers are consistently over-estimated while others that they are consistently under-estimated!). In the U.K., the numbers are 120,000 and 10,0002.

How many words do you need to learn?

An analysis of English vocabulary* has found that the first 1000 words account for 84.3% of the words used in conversation, 82.3% of the words encountered in fiction, 75.6% of the words in newspapers, and 73.5% of the words in academic texts. The second 1000 accounts for about another 5% (specifically, 6% of conversation, 5.1% of fiction, 4.7% of newspapers, 4.6% of academic texts).

Subliminal learning achieved notoriety back in 1957, when James Vicary claimed moviegoers could be induced to buy popcorn and Coca-Cola through the use of messages that flashed on the screen too quickly to be seen. The claim was later shown to be false, but though the idea that people can be brainwashed by the use of such techniques has been disproven (there was quite a bit of hysteria about the notion at the time), that doesn’t mean the idea of subliminal learning is crazy.

While parents and teachers have always strongly supported small class sizes, their belief has not always been supported by evidence. Part of the problem lies in that word “small” — what constitutes a small class? Different interventions have looked at reducing class sizes from 40 to 30, or 30 to 25. It may well be that such reductions are not sufficient to show clear benefits.

As I said in my discussion of different scripts, Russian uses the Cyrillic alphabet. Here it is (the 3rd column shows the English counterpart):

А  а   a

Б  б   b

В  в   v

Г  г   g

Д  д   d

Е  е   ye

Stimulating activities

A 5-year study1 involving 488 people age 75 to 85 found that, for the 101 people who developed dementia, the greater the number of stimulating activities (reading, writing, doing crossword puzzles, playing board or card games, having group discussions, and playing music) they engaged in, the longer rapid memory loss was delayed. Similarly, a study2 involving 1321 randomly selected people aged 70 to 89, of whom 197 had mild cognitive impairment, has found that reading books, playing games, participating in compute

"Consolidation" is a term that is bandied about a lot in recent memory research. Here's my take on what it means.

Becoming a memory

Initially, information is thought to be encoded as patterns of neural activity — cells "talking" to each other. Later, the information is coded in more persistent molecular or structural formats (e.g., the formation of new synapses). It has been assumed that once this occurs, the memory is "fixed" — a permanent, unchanging, representation.

We all know that lack of sleep makes us more prone to attentional failures, more likely to make mistakes, makes new information harder to learn, old information harder to retrieve ... We all know that, right? And yet, so many of us still go to bed too late to get the sleep we need to function well. Of course, some of us go to sleep early enough, we just can’t get to sleep fast enough, or are prone to waking in the night. (Personally, I can count the times I’ve slept through the night without waking in the last fifteen years on my fingers).